CMID™ (Cavity Margin Infusion Device)

(The balloon is etched/drilled with small pores for the efflux of drug and fluid from inside the balloon into the tissue. The balloon can also be double-walled to economize on the volume of the therapeutic solution.)


The CMID™ (Cavity Margin Infusion Device) is a new way to treat cancerous tumors in the brain (and possibly other organs such as liver and prostate). When a tumor is removed, a cavity is formed. The cancer is treated with traditional methods, such as chemotherapy, but the treatment is diffused through blood and is not a direct administration to the affected area.

The CMID™ is a balloon device that is surrounded by porous catheters. The balloon is inserted into the cavity, inflated to fill the cavity, adheres to the margin (wall), and delivers dye or other liquids at a controlled flow rate. Treatment of the cells around the tumor location can be treated this way.








Special features

  • The CMID™ is the only device that can infuse from within margins of a resection cavity at a high flow rate
  • Treats brain cancer from inside a cavity created in the tumor mass
  • Infuses chemotherapeutic drugs into a cavity through porous balloon or microporous hollow catheters
  • Distribution of chemotherapeutic drugs directly to cancer cells
  • Prevents further treatment and cancer recurrence
  • The CMID™ technology allows mapping of distribution of the amount within different regions of the brain
  • Improves patient recovery results




After a cancerous brain tumor is surgically removed, a cavity is created. Cancer cells may remain in the cavity, and chemotherapy is necessary to kill the cells. One way to do this would be to use the CMID™.

The CMID™ is a new device created to deliver chemo drugs directly into the cavity with a myriad of ports so that channels of easy flow do not compromise the distribution. It consists of a compliant balloon catheter with micro-ports or with microporous hollow fiber catheters affixed to its outer surface. When the porous balloon is expanded to the margins of the resection cavity, they are pressed into the walls of the cavity, promoting direct flow into the adjacent parenchyma.

The enhanced flow rates made possible by the porous balloon will allow substantial direct chemotherapy to be administered into the cavity margin immediately after tumor resection, reducing the chances of recurrence, and eliminating the need for additional surgical procedures.

It has been advocated in the past that an inside-out approach may be a better method to achieve uniform distribution of infused fluid in the resection cavity margin.  The CMID is a specific realization of this strategy, relying on two key components.  First, as already realized in the past, a balloon is used to fill the resection cavity and to limit the leakage of fluid from the cavity boundary into adjacent regions of cerebrospinal fluid (CSF).   Second, we overcome the principal limitations observed in previous studies, namely the severely limited flow rates that could be used, and the need for a separate surgical procedure.  In the CMID, infusate sources are distributed throughout the balloon, and in particular, the small pores have high resistance to match that of the tissue to fluid flow (Fig 4).  The effectiveness of these in allowing uniform efflux despite variations of the tissue properties adjacent to these ports has been demonstrated in both in vitro (Fig 5) and in vivo (Fig 6) studies.



Materials needed to produce the CMID™:

  • Balloon
  • Procedure to produce micro-ports






The CMID™ is covered by United States Utility Patent:  9,757,543












For additional information, licensing opportunities, and a full prospectus on the CMID™ contact:




VP of Business Development